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And...that's why we shouldn't do it.
People said the same things in the 1960's during the Apollo program.
And before that with flight.
And before that with exploration.
And...
And so on and so on.
It would be insanely difficult, but 1000x less difficult than a space colony.
Actually, much harder given the pressure involved.
The same is true of space colonization (not exploration). Given the stuff you'd have to do in order to make it work (including a lot of what are essential human experiments on babies and children), it's not worth it. Any more than it's worth establishing an undersea colony.
Welp, that's certainly a take. For some folks it was too hard to set off and look for land in the New World and for some it was too hard to expand the United States out west. But exploration (and more to the point, the spirit of exploration) drives innovation and the problems you mentioned will eventually be overcome.
